The field research was carried out in the years 2006-2008, on the experimental farm Czesławice, a part of the University of Life Sciences in Lublin. The field experiment was set up with the randomised blocks method, in four replications, on loess soil. The purpose of the work was to determine the influence of three mixtures of herbicides: Afalon + Sencor (linuron + metrybuzyna), Afalon + Brasiherb (linuron + chlomazon), Afalon + Dual (linuron + metolachlor) on weed infestation and yielding of five cultivars of soybean (Vision, Augusta, Nawiko, Mazowia and Aldana). Application of different mixtures of herbicides did not differentiate significantly the weed infestation and yielding in the canopy of soybeans. Herbicides Afalon and Dual limited the number of weeds in canopy of soybean, and first of all reduced Echinochloa cruss-galli and Elymus repens.