In 2007-2008 a study was performed at the Agricultural Experimental Station of Uhrusk on effect of tillage system on yield and grain quality of durum wheat cv. Floradur. It was set up in the split-plots design with three replications, on plots of 24 m2. The grey-brown rendzina soil, formed from light loam, weak sandy, was classified in the very good rye-type soil utility complex. The experiment concentrated on two tillage systems: ploughing and no-ploughing tillage (with cultivator after harvest; or herbicides after harvest) and two doses of nitrogen (90 and 150 kg ha-1). The dose of nitrogen of 150 kg ha-1 increased the grain yield of durum wheat by 0.54 tha-1 (16.3%), in relation to the dose of 90 kgha-1. The higher dose of nitrogen increased the total protein content, wet gluten content in grain and total ash content in relation to the dose of 90 kg ha-1. The tillage system had an effect on grain quality of durum wheat. Ploughing system increased wet gluten content in grain and test weight of grain, in relation to the no-ploughing tillage.